Compare CDMOs specializing in biologics drug substance manufacturing for monoclonal antibodies, recombinant proteins, and other biologic modalities. Filter by expression system, scale, and regulatory track record.
529 companies listed
Biologics drug substance (DS) manufacturing produces the active biologic molecule through cell culture or fermentation, followed by purification. This is the most capital-intensive and technically demanding phase of biologic drug manufacturing, requiring specialized facilities, equipment, and scientific expertise.
Expression system selection is fundamental. CHO (Chinese Hamster Ovary) cells dominate monoclonal antibody production, typically at 2,000L-15,000L scale. E. coli fermentation is used for simpler proteins and peptides. Yeast (Pichia pastoris) handles certain glycoprotein products. Each system has different upstream, downstream, and analytical requirements.
Turkey
ABFEN FARMA is a pharmaceutical CDMO offering comprehensive services.
Italy
AM Instruments is a pharmaceutical CDMO offering comprehensive services.
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Germany
Berlin‑Chemie (Menarini Group) is a pharmaceutical CDMO offering comprehensive services.
