Compare CDMOs with viral vector manufacturing capabilities for AAV, lentiviral, retroviral, and adenoviral vector production at GMP scale.
Viral vector manufacturing produces the delivery vehicles for gene therapies and some vaccines. AAV (adeno-associated virus) vectors are the most in-demand, used in approved gene therapies for hemophilia, spinal muscular atrophy, and inherited retinal disease. Lentiviral vectors are used for ex vivo cell therapy manufacturing (CAR-T). Adenoviral vectors serve vaccine platforms.
Production scale and yield are the central challenges. AAV manufacturing typically uses transient transfection of HEK293 cells or baculovirus/Sf9 insect cell systems, with titers significantly lower than monoclonal antibody production. Downstream processing (purification, concentration, formulation) is complex due to the need to separate full from empty capsids, remove host cell DNA, and achieve high purity while maintaining vector potency.
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